Abstract
Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.
Keywords: Cyclodextrins, protein refolding, Bacillus anthracis, Cryptosporidium spp., Human Immunodeficiency Virus, immunomodulation, Leishmania spp., Plasmodium spp.
Mini-Reviews in Medicinal Chemistry
Title: Cyclodextrins: More than Pharmaceutical Excipients
Volume: 10 Issue: 8
Author(s): F.J. Otero-Espinar, A. Luzardo-Alvarez and J. Blanco-Mendez
Affiliation:
Keywords: Cyclodextrins, protein refolding, Bacillus anthracis, Cryptosporidium spp., Human Immunodeficiency Virus, immunomodulation, Leishmania spp., Plasmodium spp.
Abstract: Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.
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Cite this article as:
Otero-Espinar F.J., Luzardo-Alvarez A. and Blanco-Mendez J., Cyclodextrins: More than Pharmaceutical Excipients, Mini-Reviews in Medicinal Chemistry 2010; 10 (8) . https://dx.doi.org/10.2174/138955710791572479
DOI https://dx.doi.org/10.2174/138955710791572479 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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