Small Molecule Antagonists of the Chemokine Receptor CCR5

Author(s): Remy C. Lemoine, Jutta Wanner

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 13 , 2010

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Abstract:

This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we will focus on the specific medicinal chemistry problems that were faced during the discovery of the molecules. We will also describe limited data from clinical development phases focusing on specific issues that arose during the clinical trials. Finally, we will touch on the mechanism of action of CCR5 antagonists.

Keywords: CCR5, HIV-1/AIDS, inflammatory diseases, medicinal chemistry, clinical trials, antagonists

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Article Details

VOLUME: 10
ISSUE: 13
Year: 2010
Page: [1299 - 1338]
Pages: 40
DOI: 10.2174/156802610791561219
Price: $65

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