CC Chemokine Receptor Small Molecule Antagonists in the Treatment of Rheumatoid Arthritis and Other Diseases: A Current View

Author(s): Jinqi Liu, J. Robert Merritt

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 13 , 2010

Become EABM
Become Reviewer

Abstract:

CC chemokines and their receptors play a key role in mediating both physiological and pathological processes. Chemokine receptors have been widely recognized as attractive drug targets by the pharmaceutical industry. A number of small molecule chemokine receptor antagonists have been developed for different disease indications, including rheumatoid arthritis (RA). This article describes the pharmacological evidence to support the therapeutic potential of targeting chemokine receptors, and highlights some of the recent progress in the field of developing small molecule antagonists for CC chemokine receptors aiming for RA and other disease applications. Furthermore, with the unsatisfactory clinical success so far, potential solutions leading to better success rates are also discussed.

Keywords: CC chemokines, CCR1, CCR2, CCR5, CCR6, Small molecule antagonist, Rheumatoid arthritis

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 10
ISSUE: 13
Year: 2010
Page: [1250 - 1267]
Pages: 18
DOI: 10.2174/156802610791561192
Price: $65

Article Metrics

PDF: 13