Multicomponent Reactions Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted β-Lactams Via Click Chemistry

Author(s): Ming Lei, Wang-Ze Song, Zu-Jin Zhan, Sun-Liang Cui, Fang-Rui Zhong

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 3 , 2011

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Three-component reaction in water was used to prepare a series of triazole substituted trans-β-lactams from the corresponding trans-4-acetoxy-lactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo- and regioselective procedure is simple, clean and efficient.

Keywords: Three-component reaction, β-lactam, 3R,4R-4-acetoxy-3-[(R)-1-((tert-butyldimethyl-silyl)oxy)-ethyl]-2-azetidinone, click reaction, triazole, stereo- and regioselective reaction, monobactams, carbacephems, carbapenems, sulfinylazetidin

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Article Details

Year: 2011
Page: [163 - 169]
Pages: 7
DOI: 10.2174/157017811795038430
Price: $65

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