Recent Advances in the Morita-Baylis-Hillman Reaction Under Microwave Irradiation

Author(s): Rodrigo O.M.A. de Souza, Leandro S.M. Miranda

Journal Name: Mini-Reviews in Organic Chemistry

Volume 7 , Issue 3 , 2010


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Abstract:

The Morita-Morita-Baylis – Hillman reaction (MMBHR) is one of the most important carbon – carbon bond forming reactions, and involves the selective atom-economical construction of a carbon – carbon bond at the α-position of an activated alkene, providing densely functionalized molecules. One of the major drawbacks of the MBHR is the low reaction rate, requiring long reaction times. In this review, the MBHR, in combination with microwave irradiation is summarized for the synthesis of highly functionalized molecules with the advantages of green process and shorter reaction times.

Keywords: Microwave irradiation, Baylis-Hillman reaction, biological activity, DABCO, conventional heating, microwave effect, nonthermal effects

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [212 - 220]
Pages: 9
DOI: 10.2174/157019310791384119
Price: $65

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