Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

Author(s): Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias, Carmen Valenzuela

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 7 , 2010

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Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.

Keywords: Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine

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Article Details

Year: 2010
Page: [635 - 642]
Pages: 8
DOI: 10.2174/138955710791384018
Price: $65

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