Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage

Author(s): M.G. Repetto, A. Boveris

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 7 , 2010

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Abstract:

Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.

Keywords: Cytoprotection, dehydroleucodine, ethanol gastric damage, gastric ulcer, inflammation, sesquiterpene lactone

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2010
Page: [615 - 623]
Pages: 9
DOI: 10.2174/138955710791383992
Price: $65

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