The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis

Author(s): P. Garner, H.U. Kaniskan.

Journal Name: Current Organic Synthesis

Volume 7 , Issue 4 , 2010

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Abstract:

Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.

Keywords: Asymmetric synthesis, azomethine ylide cycloaddition, cyanocycline A, multicomponent reaction, pyrrolidine synthesis

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Page: [348 - 362]
Pages: 15
DOI: 10.2174/157017910791414517
Price: $65

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