Recent Advances in the Development of MMPIs and APNIs Based on the Pyrrolidine Platforms

Author(s): X. Li, J. Li

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 9 , 2010

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Abstract:

Pyrrolidine scaffold has been widely used to design a variety of N-heterocyclic derivatives towards various targets. Amongst them, matrix metalloproteins (MMPs) and aminopeptidase N (APN) represent two kinds of important metalloproteinase targets which have been proved to be tightly related to tumor proliferation, invasion, metastasis and angiogenesis. As a result, their respective inhibitors, namely MMP inhibitors (MMPIs) and APN inhibitors (APNIs), have been systematically studied in our group for many years. Recent advances in the elucidation of MMPIs and APNIs based on the pyrrolidine platforms are briefly reviewed in this paper.

Keywords: MMPIs, APNIs, pyrrolidine, design, anticancer

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Article Details

VOLUME: 10
ISSUE: 9
Year: 2010
Page: [794 - 805]
Pages: 12
DOI: 10.2174/138955710791608334
Price: $65

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