Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities

Title: Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities

Volume: 8 Issue: 4

Author(s): Verena K. Capellini, Andrea C. Celotto, Caroline F. Baldo, Vania C. Olivon, Fernanda Viaro, Alfredo J. Rodrigues and Paulo R.B. Evora

Affiliation:

Keywords: Endothelium, nitric oxide, diabetes, vascular dysfunction, oxidative stress, antioxidants, advanced glycation endproducts

Abstract: The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. It is also known that hyperglycemia-induced oxidative stress plays a role in the development of this dysfunction. This review considers the basic physiology of the endothelium, especially related to the synthesis and function of nitric oxide. We also discuss the pathophysiology of vascular disease associated with DM. This includes the role of hyperglycemia in the induction of oxidative stress and the role of advanced glycation end-products. We also consider therapeutic strategies.

Cite this article as:

K. Capellini Verena, C. Celotto Andrea, F. Baldo Caroline, C. Olivon Vania, Viaro Fernanda, J. Rodrigues Alfredo and R.B. Evora Paulo, Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities, Current Vascular Pharmacology 2010; 8 (4) . https://dx.doi.org/10.2174/157016110791330834