Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones

Author(s): Raid J. Abdel-Jalil, Ehab Al-Momani, Lubna Tahtamooni, H.-Juergen Machulla, Wolfgang Voelter.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 5 , 2010

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A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4- methyl-1-thyl-1-piperazinyl)- 2-thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.

Keywords: Quinazolinone derivatives, piperazine derivatives, anticancer activity

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Article Details

Year: 2010
Page: [360 - 366]
Pages: 7
DOI: 10.2174/157017810791514751
Price: $65

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