N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives

Author(s): Adriano Mollica, Federica Feliciani, Azzurra Stefanucci, Ivana Cacciatore, Catia Cornacchia, Domenica Torino, Francesco Pinnen

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 7 , 2010

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It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.

Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [925 - 929]
Pages: 5
DOI: 10.2174/092986610791306760
Price: $65

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