PET and SPECT Imaging of the NMDA Receptor System: An Overview of Radiotracer Development

Author(s): F. Sobrio, G. Gilbert, C. Perrio, L. Barre, D. Debruyne

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 9 , 2010

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Imaging the N-methyl-D-aspartate receptors (NMDARs) in the living human brain by positron emission tomography (PET) or single photon emission computed tomography (SPECT) would provide useful information on the role of these receptors in ischemia and in various neurological disorders such as degenerative diseases, epilepsy or schizophrenia. To assess NMDAR radiotracer development and to propose perspectives, we overviewed the PET and SPECT candidate radioligands developed until now. Labelled molecules of interest were classified in three groups according to their binding site: intrachannel pore site blockers, glycine site inhibitors and NR2B selective subunit antagonists.

Keywords: Imaging, NMDA receptors, PET, radiotracer, radiopharmaceutical, SPECT

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [870 - 886]
Pages: 17
DOI: 10.2174/138955710791608299
Price: $65

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