Bacterial Contamination of Platelets and Septic Transfusions: Review of the Literature and Discussion on Recent Patents About Biofilm Treatment

Author(s): Vincenzo Savini, Chiara Catavitello, Daniela Astolfi, Andrea Balbinot, Gioviana Masciarelli, Arianna Pompilio, Anna M. Quaglietta, Patrizia Accorsi, Giovanni Di Bonaventura, Claudio D'Amario, Domenico D'Antonio, Antonio Iacone.

Journal Name: Recent Patents on Anti-Infective Drug Discovery

Volume 5 , Issue 2 , 2010

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Abstract:

In spite of the improvements in transfusion safety occurred in the last decades, platelet septic transfusions still represent a cause for concern. Microbial screening of blood products cannot ensure transfusion sterility, so that pathogen inactivation methods and a timely management of infectious events actually play the most relevant role. Biofilm production has been associated to several human illnesses; also, it promotes bacterial adherence to platelet bags and colonization of recipients catheter after transfusion. Therefore, facing biofilm communities is required to reduce the contamination risk and the occurrence of post-infusion events. In this context, the use of tigecycline as a wide-spectrum antibiofilm drug is discussed, along with recent patents about biofilm treatment by quorum-sensing blockers, bacteriophage-based therapy and antibiofilm oral compounds.

Keywords: Transfusion, platelet, biofilm, bacteremia, sepsis, septicaemia, tigecycline, glycylglycine

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2010
Page: [168 - 176]
Pages: 9
DOI: 10.2174/157489110791233531
Price: $58

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