Towards Characteristics of Photodynamic Drugs Specifically Aimed at Microvascular Diseases

Author(s): Jingquan Zhao, Hong Deng, Jie Xie, Xin Liu, Yang Zhang, Naiyan Huang, Ying Gu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 4 , 2010

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Photodynamic therapy (PDT) is a versatile methodology to treat various diseases but the drugs (photosensitizers) specifically aimed at individual character of diseases are urgently needed. Among those, the perilenoquinoid photosensitizers were thought of low PDT effectiveness to solid tumors due to low absorption on the “photodynamic window” but may be specially suitable for PDT to some microvascular diseases, such as age-related macular degeneration (AMD) and port wine stains (PWS), as well as other superficial diseases. Two strategies were discussed to convert the photosensitizers into clinically acceptable drugs in consideration of the drug-delivery and biological activity.

Keywords: Photodynamic therapy (PDT), Photosensitizers, Solid tumor, Microvascular disease, Target-related characteristic drug, Drug delivery, Biological activity, Drug preparation

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Article Details

Year: 2010
Page: [332 - 341]
Pages: 10
DOI: 10.2174/138955710791330963
Price: $65

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