Naturally Occurring and Synthetic Bioactive Molecules as Novel Non-Nucleoside HBV Inhibitors

Author(s): Peng Zhan, Xuemei Jiang, Xinyong Liu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 2 , 2010


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Abstract:

Hepatitis B virus (HBV) infection is a severe health problem all over the world. However, there is still no satisfactory anti-HBV therapeutic strategy. Currently, promising alternative approaches toward the control of HBV infection include the development of structurally novel and more potent inhibitors obtained from natural products and structural modifications of synthetic molecules as seen in many cases. In this review, we will focus our interest on representative naturally occurring and synthetic small molecule non-nucleoside inhibitors with high anti-HBV potency and potential for future therapeutic regimens to combat HBV infection.

Keywords: HBV, Inhibitor, Non-nucleoside inhibitor, Chemotherapeutics, Natural products, Synthetic molecules, Heterocyclic compounds

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2010
Page: [162 - 171]
Pages: 10
DOI: 10.2174/138955710791185118
Price: $65

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