Current Review of Small Molecule Ret Kinase Inhibitors

Author(s): W.J. Zuercher, B.J. Turunen, K.E. Lackey

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 2 , 2010


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Abstract:

Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors. This review details current efforts to discover novel small molecule Ret kinase inhibitiors. Furthermore, we compile a comprehensive list of Ret kinase inhibitors and describe clinical results of advanced assets with Ret inhibitory activity.

Keywords: Ret kinase, protein tyrosine kinase inhibitors, thyroid cancer

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2010
Page: [138 - 146]
Pages: 9
DOI: 10.2174/138955710791185154
Price: $65

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