Title: Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo
VOLUME: 10 ISSUE: 2
Author(s):Jinfeng Xing, Liandong Deng, Shutao Guo, Anjie Dong and Xing-Jie Liang
Affiliation:Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China.
Keywords:Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time
Abstract: Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.
