Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo

Author(s): Jinfeng Xing, Liandong Deng, Shutao Guo, Anjie Dong, Xing-Jie Liang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 2 , 2010


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Abstract:

Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.

Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2010
Page: [126 - 137]
Pages: 12
DOI: 10.2174/138955710791185127
Price: $65

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