Niacin: From Mechanisms of Action to Therapeutic Uses

Author(s): M.A Al-Mohaissen, S.C. Pun, J.J Frohlich

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 3 , 2010

Become EABM
Become Reviewer
Call for Editor


Niacin has broad spectrum lipid modifying and anti-atherosclerotic properties. It is the most effective medication available for raising raise high density lipoprotein (HDL) levels. Despite statin therapy there remains a considerable residual cardiovascular risk attributed to low HDL levels. Currently, statins decrease cardiovascular events and death by about 25-40%. Trials with surrogate endpoints have shown a decrease in endpoints by 60-90% when a combination of statin and niacin has been used. There is a growing interest in niacin in combination therapy to fill the treatment gap by modifying lipid parameters other than low density lipoprotein cholesterol. This review addresses the role of niacin in comprehensive lipid management with an emphasis on its mechanism of action, formulations, side effects, evidence from clinical trials and also focuses on practical issues related to niacin therapy.

Keywords: Niacin, nicotinic acid, mechanism of action, receptors, GPR109A, high density lipoprotein, side effects, clinical trials

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [204 - 217]
Pages: 14
DOI: 10.2174/138955710791185046
Price: $65

Article Metrics

PDF: 12