Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3)

Author(s): Moniola S. Olusanjo, Caroline P. Owen, Sabbir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 5 , 2010

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We report the use of steroid-based compounds as probes for the active site of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds were good inhibitors of 17β-HSD3 – a number were extremely potent with respect to the standard compounds used.

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound

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Article Details

Year: 2010
Page: [365 - 369]
Pages: 5
DOI: 10.2174/157018010791163505
Price: $65

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