Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds

Author(s): Junzhu Pan, Qianqian Wang, Gu He, Liang Ouyang, Li Guo

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 5 , 2010

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Abstract:

Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by 1H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.

Keywords: Analgesic, Calcium antagonist, Synthesis, Hot-plate test, L-amino acid

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2010
Page: [359 - 364]
Pages: 6
DOI: 10.2174/157018010791163497
Price: $65

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