Design, Synthesis and Evaluation of Tacrine Based Acetylcholinesterase Inhibitors

Author(s): Yanhong Shen, Youzhu Yu, Huichao Lv, Liping Feng, Guoqiang Zhang

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 5 , 2010

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Abstract:

A series of tacrine based cholinesterase inhibitors was designed, synthesized and assayed for their biological activity. Among them, five compounds inhibited acetylcholinesterase in micromolar range and most of the compounds demonstrated much better selectivity for AChE than reference compound tacrine.

Keywords: Alzheimer's disease, Acetylcholinesterase, Butyrylcholinesterase, Inhibitors, Tacrine

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2010
Page: [341 - 345]
Pages: 5
DOI: 10.2174/157018010791163532
Price: $65

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