Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment

Author(s): M. Gallagher, A. Bakker, M.A. Yassa, C.E.L. Stark

Journal Name: Current Alzheimer Research

Volume 7 , Issue 3 , 2010

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Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease.

Keywords: Memory, mild cognitive impairment, hippocampus, dentate gyrus/CA3, pattern separation, pattern completion, animal models, neuroimaging

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [197 - 199]
Pages: 3
DOI: 10.2174/156720510791050867
Price: $65

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