Review of 5-HT4R Ligands: State of Art and Clinical Applications

Author(s): Ronan Bureau, Michel Boulouard, Francois Dauphin, Frank Lezoualc'h, Sylvain Rault

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 5 , 2010

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This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT4R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.

Keywords: Serotonin, 5-HT4 receptor ligands, Agonists, Antagonists, Clinical applications

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [527 - 553]
Pages: 27
DOI: 10.2174/156802610791111551
Price: $65

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