Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

Author(s): Jose Brea, Julio Castro-Palomino, Sandra Yeste, Elena Cubero, Antonio Parraga, Eduardo Dominguez, Maria Isabel Loza

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 5 , 2010

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5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.

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Article Details

Year: 2010
Page: [493 - 503]
Pages: 11
DOI: 10.2174/156802610791111524
Price: $65

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