Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

Author(s): Simon E. Ward, Jeannette M. Watson

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 5 , 2010

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This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor

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Article Details

Year: 2010
Page: [479 - 492]
Pages: 14
DOI: 10.2174/156802610791111533
Price: $65

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PDF: 11