The First Kinetic Enzymatic Resolution of Methyl Ester of C75

Author(s): Kuheli Chakrabarty, Cristina Forzato, Patrizia Nitti, Giuliana Pitacco, Ennio Valentin

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 3 , 2010

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Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.

Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I

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Article Details

Year: 2010
Page: [245 - 248]
Pages: 4
DOI: 10.2174/157017810791112405
Price: $65

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