Oxazolidin-2-one as Efficient Ligand for the Copper-Catalyzed N-arylation of Pyrrole, Imidazole and Indole

Author(s): Hengchang Ma, Shang Wu, Qiangsheng Sun, Ziqiang Lei

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 3 , 2010

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Oxazolidin-2-one was found to be a facile ligand for the N-arylation of pyrrole, indole, and imidazole with aryl and heteroaryl iodides, bromides, and chlorides by applying CuI as catalyst. The easy preparation, commercial availability, lower molecular weight, and broad substrate applicability, as well as substituent compatibility of this catalysis system render oxazolidin-2-one great advantages over the Cu-catalyzed methods that have already been utilized in a number of applications.

Keywords: Copper, coupling, catalysis, ligands, arylations

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Article Details

Year: 2010
Page: [212 - 218]
Pages: 7
DOI: 10.2174/157017810791112496
Price: $65

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