Title: Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents
VOLUME: 9 ISSUE: 14
Author(s):Guizhi Xiao, Hao Fang, Chengguo Xing and Wenfang Xu
Affiliation:Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong, University, Jinan 250012, P.R. China.
Keywords:Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor
Abstract: Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
