Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Author(s): Yuya Asanomi, Yumiko Kobayashi, Hiroki Sakai, Takuya Masuda, Xinjiang Chen, Yoshiro Chuman, Kohei Uosaki, Kazuyasu Sakaguchi

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 4 , 2010

Become EABM
Become Reviewer
Call for Editor


We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Aβ(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

Keywords: , amyloid, atomic force microscopy, bionanomaterial, fibril formation, self-assembly

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Published on: 01 March, 2012
Page: [458 - 463]
Pages: 6
DOI: 10.2174/092986610790963618
Price: $65

Article Metrics

PDF: 4