Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Author(s): Yuya Asanomi, Yumiko Kobayashi, Hiroki Sakai, Takuya Masuda, Xinjiang Chen, Yoshiro Chuman, Kohei Uosaki, Kazuyasu Sakaguchi

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 4 , 2010


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Abstract:

We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Aβ(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

Keywords: , amyloid, atomic force microscopy, bionanomaterial, fibril formation, self-assembly

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2010
Published on: 01 March, 2012
Page: [458 - 463]
Pages: 6
DOI: 10.2174/092986610790963618
Price: $65

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