A novel sulfhydryl-β-D-glucose cholesterol 10a-10f as ligand for brain targeting liposomes was designed and synthesized. 10e was applied to the preparation of liposomal delivery system for achieving the brain-targeted delivery of the model drug tegafur in mice utilizing the glucose transporter member 1 (GLUT1). The results suggest the feasibility to enhance liposomes ability of delivering drug to brain by using the designed compound as liposome ligands.
Keywords: Blood-brain barrier, Liposome ligands, GLUT1, Brain-targeted delivery, Synthesis, Tegafur
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Published on: 01 March, 2012
Page: [281 - 289]