Design, Synthesis and In Vivo Evaluation of Sulfhydryl β-D-Glucose Cholesterols as Ligands for Brain Targeting Liposomes

Author(s): Wei Fan, Chengyi Yan, Shan Qian, Nian Yao, Lei Tang, Yong Wu

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 4 , 2010

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A novel sulfhydryl-β-D-glucose cholesterol 10a-10f as ligand for brain targeting liposomes was designed and synthesized. 10e was applied to the preparation of liposomal delivery system for achieving the brain-targeted delivery of the model drug tegafur in mice utilizing the glucose transporter member 1 (GLUT1). The results suggest the feasibility to enhance liposomes ability of delivering drug to brain by using the designed compound as liposome ligands.

Keywords: Blood-brain barrier, Liposome ligands, GLUT1, Brain-targeted delivery, Synthesis, Tegafur

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [281 - 289]
Pages: 9
DOI: 10.2174/157018010790945788
Price: $65

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