3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors

Title: 3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors

Volume: 7 Issue: 4

Author(s): Khalid Mohammed Khan, Sumbul Ahmed, Sajjad Hussain, Nida Ambreen, Shahnaz Perveen and M. Iqbal Choudhary

Affiliation:

Abstract: 3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC50 values between 61- 402 iM. The activities were compared with the standard 7-deazaxanthine (IC50 = 39.28 ± 0.76 iM).

Cite this article as:

Khan Mohammed Khalid, Ahmed Sumbul, Hussain Sajjad, Ambreen Nida, Perveen Shahnaz and Choudhary Iqbal M., 3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945805