3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors

Author(s): Khalid Mohammed Khan, Sumbul Ahmed, Sajjad Hussain, Nida Ambreen, Shahnaz Perveen, M. Iqbal Choudhary

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 4 , 2010


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Abstract:

3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC50 values between 61- 402 iM. The activities were compared with the standard 7-deazaxanthine (IC50 = 39.28 ± 0.76 iM).

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Published on: 01 March, 2012
Page: [265 - 268]
Pages: 4
DOI: 10.2174/157018010790945805
Price: $65

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