Synthesis, Characterization and Evaluation of Cytotoxicity of New Aminophosphonic Acid Diesters in Human Leukemia Cells

Author(s): Avula Balakrishna, Kishore K. Chiruvella, Mudumala V.N. Reddy, Rajesh Reddy, Sandip K. Nayak, Sathees C. Raghavan, Cirandur S. Reddy

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 4 , 2010

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A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, 1H, 13C, 31P, 19F NMR, and mass spectra. All the title compounds were evaluated for in vitro cytotoxicity against leukemic cell line derived from Tcells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g (with IC50 value of 6 iM) had emerged as lead compound.

Keywords: Aminophosphonate, Fluorine, TMG, Synthesis, Leukmia, CEM cell, Cytotoxicity

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Article Details

Year: 2010
Page: [250 - 259]
Pages: 10
DOI: 10.2174/157018010790945841
Price: $65

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