Current and Novel Therapies for Hepatitis B Virus Infection

Author(s): K. Sato, M. Mori

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 1 , 2010

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Many therapeutic reagents for hepatitis B virus infection have established efficacy in goals such as alanine aminotransferase normalization, hepatitis B virus DNA suppression, HBeAg seroconversion, histological improvement, and reduce disease progression. However, it is not established that the efficacy of these reagents for the long-term survival and prevention of hepatocellular carcinoma although recent meta-analyses have also shown antiviral therapy to be efficacious. This article reviews the current status and innovative new options for antiviral therapy for hepatitis B and also discusses the various mechanisms of action for each drug, the results of clinical studies for each therapy, and the problems yet to be solved with respect to hepatitis B treatment.

Keywords: Hepatitis B virus, therapy, host cellular target, life cycle, interferon, nucleoside/nucleotide analog, adverse effects, drug resistance

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [20 - 31]
Pages: 12
DOI: 10.2174/138955710791112613

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