Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53

Author(s): R. Ito, H. Kanno, A. Takahashi, R. Matsumoto, N. Kobayashi, T. Yoshida, T. Saito

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 5 , 2010

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Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.

Keywords: Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal

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Article Details

Year: 2010
Page: [610 - 615]
Pages: 6
DOI: 10.2174/092986610791112639
Price: $65

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