Antiphospholipid Syndrome as a Neurological Disease

Author(s): Carlos Ewerton Maia Rodrigues, Jozelio Freire Carvalho, Yehuda Shoenfeld

Journal Name: Current Rheumatology Reviews

Volume 6 , Issue 1 , 2010

Become EABM
Become Reviewer
Call for Editor


Neurologic disorders are among the most comum and important clinical manifestations associated with the antiphospholipid syndrome (APS), mainly those that affects the central nervous system (CNS). These include sroke, transient ischemic attack, Sneddons syndrome, convulsions/epilepsy, dementia, cognitive deficits, headaches/migraine, chorea, multiple sclerosis-like, transverse myelitis, ocular symptoms and Guillain-Barre syndrome. On the other hand, only one study investigated the occurrence of peripheral neuropathy and showed alterations in 35 of PAPS patients. The proposed mechanisms of nervous system involvement in APS are: thrombosis, and antiphospholipid antibodiesbinding CNS, leading to deregulation of its functions. This article updates the data regarding the clinical aspects related to major neurologic manifestations associated to antiphospholipid syndrome.

Keywords: Antiphospholipid syndrome, Hughes'syndrome, antiphospholipid antibodies, neurological manifestations

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [12 - 17]
Pages: 6
DOI: 10.2174/157339710790827678

Article Metrics

PDF: 14