Chemistry of Tumour Targeted T1 Based MRI Contrast Agents

Author(s): Nazila Kamaly, Andrew D. Miller, Jimmy D. Bell

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 12 , 2010

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For effective tumour imaging by magnetic resonance imaging (MRI) there is a clear need to develop organ, tissue and cell specific contrast agents that can selectively bind to tumour biomarkers. The versatility of a range of bioconjugation techniques and facile coupling chemistries has facilitated the synthesis of MRI contrast agents bearing tumour targeting moieties that comprise small molecule affinity ligands, peptides, antibodies and even proteins. The aim of this review is to describe the development and implementation of tumour targeted T1 MRI contrast agents, with an emphasis on the chemistry used to modify pre-existing clinical MRI contrast agents for targeted tumour imaging.

Keywords: MRI, MRI contrast agents, Gadolinium, Cancer, Tumour, Tumour targeting, T1 contrast agents, Nanoparticles, Nanomedicine, Paramagnetic contrast agents

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Article Details

Year: 2010
Page: [1158 - 1183]
Pages: 26
DOI: 10.2174/156802610791384199
Price: $65

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