Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Jing, Li; Wenlong, Huang; Huibin, Zhang; Huiping, Zhou

Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Author(s): Jing Li, Wenlong Huang, Huibin Zhang, Huiping Zhou

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Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 3 , 2010

DOI : 10.2174/157018010790596614

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The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.

Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity

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Letters in Drug Design & Discovery

Title: Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

VOLUME: 7 ISSUE: 3

Author(s):Jing Li, Wenlong Huang, Huibin Zhang and Huiping Zhou

Affiliation:School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Keywords:Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity

Abstract: The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.

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Jing Li, Wenlong Huang, Huibin Zhang and Huiping Zhou, “ Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives”, Letters in Drug Design & Discovery (2010) 7: 176. https://doi.org/10.2174/157018010790596614

DOI https://doi.org/10.2174/157018010790596614	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010

Page: [176 - 181]
Pages: 6
DOI: 10.2174/157018010790596614
Price: $65

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