Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Author(s): Jing Li, Wenlong Huang, Huibin Zhang, Huiping Zhou

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 3 , 2010

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Abstract:

The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.

Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [176 - 181]
Pages: 6
DOI: 10.2174/157018010790596614
Price: $65

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