Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein

Author(s): Dessislava Georgieva, Lars Redecke, Martin von Bergen, Nicolay Genov, Chrsitian Betzel

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 3 , 2010

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In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.

Keywords: Three-dimensional structure, structural transformation, ginkgolide, prion protein, protein misfolding

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Article Details

Year: 2010
Page: [399 - 404]
Pages: 6
DOI: 10.2174/092986610790780314
Price: $65

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