Title: A Novel Approach to Predict Protein-Protein Interactions Related to Alzheimers Disease Based on Complex Network
VOLUME: 17 ISSUE: 3
Author(s):Jie Yang and Xiong-Fei Jiang
Affiliation:State Key Laboratory of Pharmaceutical Biotechnology, Life Science College, Nanjing University, 22 Hankou Road, Nanjing 210093, P.R. China.
Keywords:AD associated protein interaction network, signal pathway, conservative interaction pattern
Abstract: A protein domain interaction prediction program was complied using C++ to predict whether a query protein could interact with other hub proteins. It is indicated that the proteins interacting with AATF (Apoptosis-Antagonizing Transcription Factor) possess a common conservative pattern: I-x(0,1)-E-x(2)-[A/E/N/T]-x-[E/K]. Our method is attempted to integrate the characteristics of protein interaction network with the simplest building blocks-conservative patterns.
