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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Anticancer Agents Derived from Natural Products

Author(s): E-Hu Liu, Lian-Wen Qi, Qian Wu, Yong-Bo Peng and Ping Li

Volume 9, Issue 13, 2009

Page: [1547 - 1555] Pages: 9

DOI: 10.2174/138955709790361520

Price: $65

Abstract

Advances in the prevention and treatment of cancer require the continued development of novel and improved chemopreventive and chemotherapeutic agents. Throughout history, natural products have afforded a rich source of anticancer agents with diverse chemical structures and bioactivities. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. In this review, we will present the anticancer activities, mechanism of action, structure and activity relationships of six important anticancer agents from natural products, that is, taxol, betulinic acid, camptothecin, resveratrol, podophyllotoxin and curcumin.

Keywords: Anticancer agents, natural products, anticancer activity, mechanism of action, structure and activity relationship


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