Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

Author(s): Laura Alaniz, Mariana Garcia, Miguel Rizzo, Flavia Piccioni, Guillermo Mazzolini

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 13 , 2009

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Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.

Keywords: Extracellular matrix, hyaluronan, CD44, immune system, dendritic cells, cancer

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Article Details

Year: 2009
Page: [1538 - 1546]
Pages: 9
DOI: 10.2174/138955709790361485
Price: $65

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PDF: 10