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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

Author(s): Laura Alaniz, Mariana Garcia, Miguel Rizzo, Flavia Piccioni and Guillermo Mazzolini

Volume 9, Issue 13, 2009

Page: [1538 - 1546] Pages: 9

DOI: 10.2174/138955709790361485

Price: $65

Abstract

Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.

Keywords: Extracellular matrix, hyaluronan, CD44, immune system, dendritic cells, cancer


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