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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mechanisms of the Resistance and Tolerance to Beta-Lactam and Glycopeptide Antibiotics in Pathogenic Gram-Positive Cocci

Author(s): A. Mlynarczyk, B. Mlynarczyk, M. Kmera-Muszynska, S. Majewski and G. Mlynarczyk

Volume 9, Issue 13, 2009

Page: [1527 - 1537] Pages: 11

DOI: 10.2174/138955709790361557

Price: $65

Abstract

Beta-lactams are the most frequently used antimicrobials in combating infections. In the case of gram-positive bacteria resistant to beta-lactams, glycopeptides are the first choice. The occurrence, mechanisms and genetic background of the resistance of pathogenic staphylococci, streptococci and enterococci to beta-lactam and glycopeptide antibiotics were discussed. The resistances to well-established antimicrobials, as well as new agents (ceftobiprole, oritavancin, telavancin, dalbavancin) were taken into consideration in the text.

Keywords: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Enterococcus faecalis, Enterococcus faecium, antibiotic resistance, SCCmec, plasmids, transposons


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