Conformations and Biological Activities of Amyloid Beta Peptide 25-35

Author(s): L. Millucci, L. Ghezzi, G. Bernardini, A. Santucci

Journal Name: Current Protein & Peptide Science

Volume 11 , Issue 1 , 2010

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Amyloid-β (Aβ) peptide is commonly found in human Alzheimers disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of Aβ in the human brain are Aβ(1-40) and Aβ(1-42), but Aβ(25-35) fragment, physiologically present in elderly people, is the more toxic region and has been recently found to play a relevant role in AD, due to its peculiar aggregation properties. In this work, we review the current understanding on the conformations and biological activity of Aβ(25-35) exploring aggregation, cytotoxic and neurodegenerative properties of this fundamental Aβ fragment, in order to provide an effective starting point to better approach a pathology spread and problematic as AD.

Keywords: Aβ(25-35), Alzheimer's disease, aggregation, amyloid, neurotoxicity, structure analysis

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Article Details

Year: 2010
Page: [54 - 67]
Pages: 14
DOI: 10.2174/138920310790274626

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