Recent Progress in Research on Ribosome Inactivating Proteins

Author(s): T. B. Ng, Jack Ho Wong, Hexiang Wang

Journal Name: Current Protein & Peptide Science

Volume 11 , Issue 1 , 2010

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The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs) including isolation and characterization of new RIPs, studies on the crystal structures and mechanisms of actions of RIPs, the use of saporin-based neurotoxins to selectively lesion cholinergic neurons in neuroscience research, and the use of RIP-based conjugates and immunotoxins in anticancer therapy.

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Article Details

Year: 2010
Page: [37 - 53]
Pages: 17
DOI: 10.2174/138920310790274662

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PDF: 142