Microencapsulation of Vaccine Antigens and Adjuvants for Mucosal Targeting

Author(s): Thejani E. Rajapaksa, David D. Lo

Journal Name: Current Immunology Reviews (Discontinued)

Volume 6 , Issue 1 , 2010


Abstract:

Delivery of vaccine antigens that can trigger potent mucosal immune response is one of the effective strategies to overcome a wide array of infectious diseases. Microencapsulation of vaccine antigens with Poly(lactide-co-glycolic acids) (PLGA), an FDA approved biodegradable polymer, has been investigated for targeted M-cell uptake. While PLGA possesses many attractive properties, a successful PLGA based mucosal-targeted vaccine has yet to be introduced. This review focuses on the physiochemical properties important in the preparation of antigen-loaded PLGA microparticles, properties that influence M-cell specific uptake, and the induction of effective immune responses. In addition, a possible role of microparticle properties in immune adjuvant activity is discussed. A careful consideration of these factors may yet lead to the development of an effective needle-free mucosal vaccine using polymer microparticles.

Keywords: M-cell targeting, PLGA, microparticles

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2010
Page: [29 - 37]
Pages: 9
DOI: 10.2174/157339510790231798

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