HLA-G - From Fetal Tolerance to a Regulatory Molecule in Inflammatory Diseases

Author(s): Tiago Degani Veit, Priscila Vianna, Jose Artur B. Chies

Journal Name: Current Immunology Reviews (Discontinued)

Volume 6 , Issue 1 , 2010


The Human Leukocyte Antigen G (HLA-G) is a non-classical class I MHC which is characterized by low polymorphism at the DNA level, limited tissue distribution in non-pathological conditions and the expression of both membrane-bound and soluble isoforms by alternative splicing. This molecule has become the object of interest because of its possible role in pregnancy maintenance. HLA-G seems to be involved in the induction and maintenance of tolerance between the mother immune system and the semi-allogeneic fetus at the fetal-placentary interface, and also seems to play an important role in embryo implantation. Besides, several studies point out to a broader immunoregulatory role for this molecule. Here we review the potential roles of the HLA-G molecule on the immune system, the unique regulatory region of its gene, the influence of gene polymorphisms on HLA-G expression, as well as several situations in which this molecule has been involved, such as pregnancy, transplantation, cancer, viral infections and, more recently, inflammatory diseases.

Keywords: HLA-G, immune regulation, genetics, pregnancy, cancer, inflammatory diseases

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Article Details

Year: 2010
Page: [1 - 15]
Pages: 15
DOI: 10.2174/1573395511006010001

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