Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase

Author(s): Keguang Cheng, Chao Wang, Jun Liu, Juan Xie, Hongbin Sun

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 2 , 2010


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Abstract:

Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.

Keywords: Glycogen phosphorylase, Oleanolic acid, C-28 derivatives, Synthesis, Inhibition

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [116 - 121]
Pages: 6
DOI: 10.2174/157018010790225921
Price: $65

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